application of hydrotropic solubilization in spectrophotometric analysis of esomeprazole and itopride pharmaceutical combined tablet dosage forms

two simple, accurate and precise methods for simultaneous estimation of esomeprazole and itopride in bulk drug and tablet dosage form have been described. method-a employs formation and solving of simultaneous equation using 231 and 370 nm as two analytical wavelengths. method -b is absorption ratio method, which uses 308 and 331 nm as two analytical wavelengths.beer’s law was obeyed in the concentration range 5-35 μg/ml for esomeprazole and 5-40 μg ml-1 for itopride. in the present investigation, 0.5 metformin hydrochloride solutions (hydrotropic solubilizing agent) were employed to solubilize, esomeprazole and itopride from fine powder of its tablets to carryout spectrophotometric analysis. the optimized methods showed good reproducibility and recovery with standard deviation of < 1.0% and percent relative standard deviation less then 2.0%, allow the simultaneous estimation of esomeprazole and itopride in concentration ranges employed for this purpose in the assay of bulk drug and tablets.